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Molecules 2017, 22(5), 808; doi:10.3390/molecules22050808

The Transcriptome of Type I Murine Astrocytes under Interferon-Gamma Exposure and Remyelination Stimulus

1
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia
2
Department of Mathematical Analysis, Faculty of Mechanics and Mathematics, Lomonosov Moscow State University, 119991 Moscow, Russia
3
Big Data and Information Retrieval School, Faculty of Computer Science, National Research University Higher School of Economics, 125319 Moscow, Russia
4
SRC Bioclinicum, 115088 Moscow, Russia
5
P. Hertsen Moscow Oncology Research Institute, 125284 Moscow, Russia
6
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia
These authors contributed equally to this work.
Current address: Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
*
Author to whom correspondence should be addressed.
Academic Editor: Chun Kwok Wong
Received: 24 March 2017 / Revised: 30 April 2017 / Accepted: 11 May 2017 / Published: 15 May 2017
View Full-Text   |   Download PDF [6332 KB, uploaded 15 May 2017]   |  

Abstract

Astrocytes are considered to be an important contributor to central nervous system (CNS) disorders, particularly multiple sclerosis. The transcriptome of these cells is greatly affected by cytokines released by lymphocytes, penetrating the blood–brain barrier—in particular, the classical pro-inflammatory cytokine interferon-gamma (IFNγ). We report here the transcriptomal profiling of astrocytes treated using IFNγ and benztropine, a putative remyelinization agent. Our findings indicate that the expression of genes involved in antigen processing and presentation in astrocytes are significantly upregulated upon IFNγ exposure, emphasizing the critical role of this cytokine in the redirection of immune response towards self-antigens. Data reported herein support previous observations that the IFNγ-induced JAK-STAT signaling pathway may be regarded as a valuable target for pharmaceutical interventions. View Full-Text
Keywords: astrocytes; transcriptome; Affymetrix; interferon-gamma; benztropine; immunoproteasome; PA28/11S/REG; antigen presentation; major histocompatibility complex; microRNA astrocytes; transcriptome; Affymetrix; interferon-gamma; benztropine; immunoproteasome; PA28/11S/REG; antigen presentation; major histocompatibility complex; microRNA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kudriaeva, A.; Galatenko, V.V.; Maltseva, D.V.; Khaustova, N.A.; Kuzina, E.; Tonevitsky, A.G.; Gabibov, A.; Belogurov, A. The Transcriptome of Type I Murine Astrocytes under Interferon-Gamma Exposure and Remyelination Stimulus. Molecules 2017, 22, 808.

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