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Molecules 2017, 22(5), 769; doi:10.3390/molecules22050769

Cs2CO3-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 311121, China
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Academic Editors: Shengyu Feng, Qingzeng Zhu, Caihong Xu and Chunming Cui
Received: 27 February 2017 / Revised: 17 April 2017 / Accepted: 5 May 2017 / Published: 18 May 2017
(This article belongs to the Special Issue Progress in Silicon and Organosilicon Chemistry)
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Abstract

It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom-economic process for this anionic trifluoromethylation of non-enolisable aldehydes and ketones. View Full-Text
Keywords: chalcone; trifluoromethylation; 1,2-addition; trifluoromethylated silyl ether chalcone; trifluoromethylation; 1,2-addition; trifluoromethylated silyl ether
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dong, C.; Bai, X.-F.; Lv, J.-Y.; Cui, Y.-M.; Cao, J.; Zheng, Z.-J.; Xu, L.-W. Cs2CO3-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers. Molecules 2017, 22, 769.

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