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Molecules 2017, 22(4), 532; doi:10.3390/molecules22040532

Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity

1
Chemistry Department, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, P.O. Box LG 56, Legon, Accra, Ghana
2
Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O. Box LG 581, Legon, Accra, Ghana
3
Department of Chemistry and Pharmacy, Friederich Alexander University of Erlangen-Nurnberg, Schuhstrasse 19, 91052 Erlangen, Germany
4
Present address: Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
*
Author to whom correspondence should be addressed.
Academic Editor: David J. Newman
Received: 27 February 2017 / Revised: 22 March 2017 / Accepted: 23 March 2017 / Published: 27 March 2017
(This article belongs to the Special Issue Natural Product: A Continuing Source of Novel Drug Leads)
View Full-Text   |   Download PDF [1776 KB, uploaded 30 March 2017]   |  

Abstract

As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, Dichapetalum pallidum, led to the isolation of the newly occurring 7-hydroxydichapetalin P (1) and the known dichapetalins A (2) and X (3). Also isolated were the known compounds friedelin-2,3-lactone (4), friedelan-3-one (6), friedelan-3β-ol (7) and pomolic (8), as well as the dipeptide aurantiamide acetate (5). The compounds were characterized by direct interpretation of their IR, 1D NMR and 2D NMR spectral data and by comparison of their physico-chemical data, including their chromatographic profiles, with the literature and authentic samples in our compound library for the genus Dichapetalum. The compounds were assayed for their anti-proliferative activities against the human T-lymphocytic leukemia (Jurkat), acute promyelocytic leukemia (HL-60) and T-lymphoblast-like leukemia (CEM) cell lines. Overall, dichapetalin X showed the strongest (3.14 μM) and broadest cytotoxic activities against all the leukemic cell lines tested, exhibiting even stronger activities than the standard compound, curcumin. View Full-Text
Keywords: Dichapetalum pallidum; 7-hydroxydichapetalin P; dichapetalin A; dichapetalin X; spiroketal; leukemia Dichapetalum pallidum; 7-hydroxydichapetalin P; dichapetalin A; dichapetalin X; spiroketal; leukemia
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MDPI and ACS Style

Osei-Safo, D.; Dziwornu, G.A.; Appiah-Opong, R.; Chama, M.A.; Tuffour, I.; Waibel, R.; Amewu, R.; Addae-Mensah, I. Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity. Molecules 2017, 22, 532.

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