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Molecules 2017, 22(4), 529; doi:10.3390/molecules22040529

New Acorane-Type Sesquiterpene from Acorus calamus L.

1
Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China
2
National Center for Natural Products Research, University of Mississippi, University MS 38677, USA
3
Key Laboratory of Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing 100053, China
4
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 5 March 2017 / Revised: 21 March 2017 / Accepted: 22 March 2017 / Published: 26 March 2017
(This article belongs to the Section Natural Products)
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Abstract

A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds 1 (10 μM), 2 (5 μM and 10 μM) and 3 (10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line. View Full-Text
Keywords: Acorus calamus L.; Araceae; acorane-type sesquiterpene; biosynthetic pathway; cell proliferation Acorus calamus L.; Araceae; acorane-type sesquiterpene; biosynthetic pathway; cell proliferation
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Li, J.; Zhao, J.; Wang, W.; Li, L.; Zhang, L.; Zhao, X.-F.; Liu, Q.-R.; Liu, F.; Yang, M.; Khan, I.A.; Li, S.-X. New Acorane-Type Sesquiterpene from Acorus calamus L.. Molecules 2017, 22, 529.

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