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Molecules 2017, 22(4), 526; doi:10.3390/molecules22040526

Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes

1
Department of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, Potenza 85100, Italy
2
SSD Sperimentazione Animale, Istituto Nazionale Tumori, IRCCS, “Fondazione G. Pascale”, Via Mariano Semmola, Napoli 80131, Italy
3
Department of Biology and Chemistry, University of Salerno, Via Giovanni Paolo II, 132, Fisciano 84084, Italy
4
Department of Pharmacy, Health and Nutritional Sciences, University Calabria, Via Pietro Bucci, Arcavacata di Rende 87036, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 25 February 2017 / Revised: 17 March 2017 / Accepted: 22 March 2017 / Published: 28 March 2017
(This article belongs to the Section Organometallic Chemistry)
View Full-Text   |   Download PDF [590 KB, uploaded 28 March 2017]   |  

Abstract

The quest for alternative drugs with respect to the well-known cis-platin and its derivatives, which are still used in more than 50% of the treatment regimens for patients suffering from cancer, is highly needed. In this context, organometallic compounds, which are defined as metal complexes containing at least one direct covalent metal-carbon bond, have recently been found to be promising anticancer drug candidates. A series of new metallocene complexes with scandium, yttrium, and neodymium have been prepared and characterized. Some of these compounds show a very interesting anti-proliferative activity in triple negative breast cancer cell line (MDA.MB231) and the non-hormone sensitive prostate cancer cell line (DU145). Moreover, the interaction of some of them with biological membranes, evaluated using liposomes as bio-membrane mimetic model systems, seems to be relevant. The biological activity of these compounds, particularly those based on yttrium, already effective at low concentrations on both cancer cell lines, should be taken into account with regard to new therapeutic approaches in anticancer therapy. View Full-Text
Keywords: breast cancer; prostate cancer; metallocene group 3; metal complexes; cytotoxic activity; cell membrane permeability breast cancer; prostate cancer; metallocene group 3; metal complexes; cytotoxic activity; cell membrane permeability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Caporale, A.; Palma, G.; Mariconda, A.; Del Vecchio, V.; Iacopetta, D.; Parisi, O.I.; Sinicropi, M.S.; Puoci, F.; Arra, C.; Longo, P.; Saturnino, C. Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes. Molecules 2017, 22, 526.

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