Synthesis and Cytotoxicity of N-Substituted Dibenzo[a,j]xanthene-3,11-dicarboxamide Derivatives
AbstractIn order to study the structure-activity relationships of xanthene derivatives, four series of N-substituted 14-aryl-14H-dibenzo[a,j]xanthene-3,11-dicarboxamide derivatives were synthesized. The structures of all compounds were identified by 1H-NMR, HR-MS and IR spectra, in which compounds 6a–h were further identified by 13C-NMR spectra. The in vitro antitumor activity of the synthesized compounds was tested by MTT assay. Most of them displayed strong inhibitory activity on human hepatocellular carcinoma cell lines (SK-HEP-1, HepG2 and SMMC-7721 cells) and acute promyelocytic leukemia NB4 cells. Compounds 6c–6e exhibited significant inhibitory activity against NB4 cells with IC50 values of 0.52 μM and 0.76 μM, respectively, much lower than 5.31 μM of the positive control As2O3. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 2034 KB)
Share & Cite This Article
Song, Y.; Yang, Y.; Wu, L.; Dong, N.; Gao, S.; Ji, H.; Du, X.; Liu, B.; Chen, G. Synthesis and Cytotoxicity of N-Substituted Dibenzo[a,j]xanthene-3,11-dicarboxamide Derivatives. Molecules 2017, 22, 517.
Song Y, Yang Y, Wu L, Dong N, Gao S, Ji H, Du X, Liu B, Chen G. Synthesis and Cytotoxicity of N-Substituted Dibenzo[a,j]xanthene-3,11-dicarboxamide Derivatives. Molecules. 2017; 22(4):517.Chicago/Turabian Style
Song, Yongbin; Yang, Yihui; Wu, Lijun; Dong, Naiwei; Gao, Shang; Ji, Hongrui; Du, Xia; Liu, Bo; Chen, Guoyou. 2017. "Synthesis and Cytotoxicity of N-Substituted Dibenzo[a,j]xanthene-3,11-dicarboxamide Derivatives." Molecules 22, no. 4: 517.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.