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Molecules 2017, 22(4), 517; doi:10.3390/molecules22040517

Synthesis and Cytotoxicity of N-Substituted Dibenzo[a,j]xanthene-3,11-dicarboxamide Derivatives

1
School of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040, China
2
College of Pharmacy, Harbin Medical University, Harbin 150081, China
3
College of Pharmacy, Harbin Medical University Daqing Campus, Daqing 163319, China
*
Author to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Received: 22 February 2017 / Revised: 16 March 2017 / Accepted: 21 March 2017 / Published: 23 March 2017
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [806 KB, uploaded 28 March 2017]   |  

Abstract

In order to study the structure-activity relationships of xanthene derivatives, four series of N-substituted 14-aryl-14H-dibenzo[a,j]xanthene-3,11-dicarboxamide derivatives were synthesized. The structures of all compounds were identified by 1H-NMR, HR-MS and IR spectra, in which compounds 6a–h were further identified by 13C-NMR spectra. The in vitro antitumor activity of the synthesized compounds was tested by MTT assay. Most of them displayed strong inhibitory activity on human hepatocellular carcinoma cell lines (SK-HEP-1, HepG2 and SMMC-7721 cells) and acute promyelocytic leukemia NB4 cells. Compounds 6c6e exhibited significant inhibitory activity against NB4 cells with IC50 values of 0.52 μM and 0.76 μM, respectively, much lower than 5.31 μM of the positive control As2O3. View Full-Text
Keywords: synthesis design; cytotoxicity; dibenzo[a,j]xanthenes; NMR spectroscopy synthesis design; cytotoxicity; dibenzo[a,j]xanthenes; NMR spectroscopy
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MDPI and ACS Style

Song, Y.; Yang, Y.; Wu, L.; Dong, N.; Gao, S.; Ji, H.; Du, X.; Liu, B.; Chen, G. Synthesis and Cytotoxicity of N-Substituted Dibenzo[a,j]xanthene-3,11-dicarboxamide Derivatives. Molecules 2017, 22, 517.

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