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Molecules 2017, 22(4), 511; doi:10.3390/molecules22040511

Silane Modified Diopside for Improved Interfacial Adhesion and Bioactivity of Composite Scaffolds

State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China
The State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China
Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha 410008, China
State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China
Human Reproduction Center, Shenzhen Hospital of Hongkong University, Shenzhen 518053, China
The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China
The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 14 February 2017 / Revised: 18 March 2017 / Accepted: 21 March 2017 / Published: 23 March 2017
View Full-Text   |   Download PDF [6646 KB, uploaded 24 March 2017]   |  


Diopside (DIOP) was introduced into polyetheretherketone/polyglycolicacid (PEEK/PGA) scaffolds fabricated via selective laser sintering to improve bioactivity. The DIOP surface was then modified using a silane coupling agent, 3-glycidoxypropyltrimethoxysilane (KH570), to reinforce interfacial adhesion. The results showed that the tensile properties and thermal stability of the scaffolds were significantly enhanced. It could be explained that, on the one hand, the hydrophilic group of KH570 formed an organic covalent bond with the hydroxy group on DIOP surface. On the other hand, there existed relatively high compatibility between its hydrophobic group and the biopolymer matrix. Thus, the ameliorated interface interaction led to a homogeneous state of DIOP dispersion in the matrix. More importantly, an in vitro bioactivity study demonstrated that the scaffolds with KH570-modified DIOP (KDIOP) exhibited the capability of forming a layer of apatite. In addition, cell culture experiments revealed that they had good biocompatibility compared to the scaffolds without KDIOP. It indicated that the scaffolds with KDIOP possess potential application in tissue engineering. View Full-Text
Keywords: diopside; silane coupling agent; interface adhesion; bioactivity; scaffolds diopside; silane coupling agent; interface adhesion; bioactivity; scaffolds

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shuai, C.; Shuai, C.; Feng, P.; Yang, Y.; Xu, Y.; Qin, T.; Yang, S.; Gao, C.; Peng, S. Silane Modified Diopside for Improved Interfacial Adhesion and Bioactivity of Composite Scaffolds. Molecules 2017, 22, 511.

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