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Molecules 2017, 22(3), 503; doi:10.3390/molecules22030503

Consecutive One-Pot versus Domino Multicomponent Approaches to 3-(Diarylmethylene)oxindoles

Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea
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Academic Editor: Richard A. Bunce
Received: 27 February 2017 / Revised: 9 March 2017 / Accepted: 17 March 2017 / Published: 22 March 2017
(This article belongs to the Collection Heterocyclic Compounds)
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Abstract

Based on consecutive one-pot conditions combining three palladium-catalyzed reactions (Sonogashira, Heck and Suzuki-Miyaura reactions), a more efficient domino multicomponent method has been successfully developed to access a wide variety of 3-(diarylmethylene)oxindoles. Microwave irradiation and use of a silver salt were the most important factors to achieve high yields and stereoselectivity. View Full-Text
Keywords: consecutive one-pot reaction; domino reaction; 3-(diarylmethylene)oxindole; palladium-catalyzed reaction; microwave irradiation consecutive one-pot reaction; domino reaction; 3-(diarylmethylene)oxindole; palladium-catalyzed reaction; microwave irradiation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Park, S.; Lee, J.; Shin, K.J.; Oh, E.; Seo, J.H. Consecutive One-Pot versus Domino Multicomponent Approaches to 3-(Diarylmethylene)oxindoles. Molecules 2017, 22, 503.

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