Next Article in Journal
Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas
Next Article in Special Issue
c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells
Previous Article in Journal
A Metabolomic Approach for the Discrimination of Red Ginseng Root Parts and Targeted Validation
Previous Article in Special Issue
The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Molecules 2017, 22(3), 469; doi:10.3390/molecules22030469

On the Emerging Role of the Taste Receptor Type 1 (T1R) Family of Nutrient-Sensors in the Musculoskeletal System

1
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan
2
Division of Molecular Signaling and Biochemistry, Department of Health Promotion, Kyushu Dental University, Kokurakita-ku, Kitakyushu, Fukuoka 803-8580, Japan
3
Division of Biomedical Science, Marian University College of Osteopathic Medicine, 3200 Cold Spring Rd., Indianapolis, IN 46222, USA
4
Bone & Mineral Research Group, Marian University College of Osteopathic Medicine, 3200 Cold Spring Rd., Indianapolis, IN 46222, USA
5
Division of Anatomy, Department of Health Promotion, Kyushu Dental University, Kokurakita-ku, Kitakyushu, Fukuoka 803-8580, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Yung Hou Wong
Received: 14 February 2017 / Revised: 10 March 2017 / Accepted: 13 March 2017 / Published: 15 March 2017
(This article belongs to the Special Issue G-protein Coupled Receptor Structure and Function)
View Full-Text   |   Download PDF [569 KB, uploaded 15 March 2017]   |  

Abstract

The special sense of taste guides and guards food intake and is essential for body maintenance. Salty and sour tastes are sensed via ion channels or gated ion channels while G protein-coupled receptors (GPCRs) of the taste receptor type 1 (T1R) family sense sweet and umami tastes and GPCRs of the taste receptor type 2 (T2R) family sense bitter tastes. T1R and T2R receptors share similar downstream signaling pathways that result in the stimulation of phospholipase-C-β2. The T1R family includes three members that form heterodimeric complexes to recognize either amino acids or sweet molecules such as glucose. Although these functions were originally described in gustatory tissue, T1R family members are expressed in numerous non-gustatory tissues and are now viewed as nutrient sensors that play important roles in monitoring global glucose and amino acid status. Here, we highlight emerging evidence detailing the function of T1R family members in the musculoskeletal system and review these findings in the context of the musculoskeletal diseases sarcopenia and osteoporosis, which are major public health problems among the elderly that affect locomotion, activities of daily living, and quality of life. These studies raise the possibility that T1R family member function may be modulated for therapeutic benefit. View Full-Text
Keywords: taste receptor; bone; skeletal muscle; sarcopenia; osteoporosis; T1R3; myogenesis; bone remodeling taste receptor; bone; skeletal muscle; sarcopenia; osteoporosis; T1R3; myogenesis; bone remodeling
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kokabu, S.; Lowery, J.W.; Toyono, T.; Sato, T.; Yoda, T. On the Emerging Role of the Taste Receptor Type 1 (T1R) Family of Nutrient-Sensors in the Musculoskeletal System. Molecules 2017, 22, 469.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top