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Molecules 2017, 22(3), 460; doi:10.3390/molecules22030460

Essential Oil Composition and Bioactivities of Waldheimia glabra (Asteraceae) from Qinghai-Tibet Plateau

1
,
2,* , 2
,
3
and
3,*
1
College of Science, Tibet University, Lhasa 8500, Tibet, China
2
School of Pharmacy, Fudan University, Shanghai 201203, China
3
School of Life Science, Fudan University, Shanghai 200438, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Olga Tzakou and Derek J. McPhee
Received: 26 December 2016 / Accepted: 11 March 2017 / Published: 13 March 2017
(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
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Abstract

Waldheimia glabra is traditionally used as incense and as an anti-influenza drug by Tibetans in China. Here, we collected W. glabra from the Gangs Rinpoche mountain at an altitude of 5200 m, and analyzed its essential oil by gas chromatography-mass spectrometry (GC-MS) combined with the retention indices (RI). Twenty-seven compounds, representing 72.4% of the total essential oil, were identified, including α-bisabolol (20.2%), valeranone (11.8%), chamazulene (9.9%), spathulenol (8.2%), β-caryophyllene (6.1%), and caryophyllene oxide (5.2%). Bioactivity evaluation of the essential oil revealed that it exhibited potent anti-influenza effect on viruses H3N2 and anti-inflammatory effect by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages, but no anti-complementary activity. View Full-Text
Keywords: Waldheimia glabra; Tibetan medicine; essential oil; anti-influenza; anti-inflammatory Waldheimia glabra; Tibetan medicine; essential oil; anti-influenza; anti-inflammatory
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De, J.; Lu, Y.; Ling, L.; Peng, N.; Zhong, Y. Essential Oil Composition and Bioactivities of Waldheimia glabra (Asteraceae) from Qinghai-Tibet Plateau. Molecules 2017, 22, 460.

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