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Molecules 2017, 22(3), 382; doi:10.3390/molecules22030382

Under-Reported Aspects of Platinum Drug Pharmacology

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Academic Editors: Ana B. Caballero and Patrick Gamez
Received: 24 January 2017 / Accepted: 27 February 2017 / Published: 28 February 2017
(This article belongs to the Special Issue Metal Based Drugs: Opportunities and Challenges)
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Abstract

Platinum drugs remain the backbone of many antineoplastic regimens. Among the numerous chemical or pharmacological effects of platinum drugs, some aspects tend to be under-reported. Thus, this perspective paper intends to stress some neglected properties of platinum drugs: first, the physico-chemical characteristics (aquation reaction kinetics) that determine site-specific toxicity; second, the impact on RNA molecules. Knowledge of the ‘RNA world’ has dramatically changed our understanding of cellular and molecular biology. The inherent RNA-crosslinking properties should make platinum-based drugs interact with coding and non-coding RNAs. Third, we will discuss the impact on the immune system, which is now recognized to substantially contribute to chemotherapy efficacy. Together, platinum drugs are in fact old drugs, but are worth re-focusing on. Many aspects are still mysterious but can pave the way to new drugs or an improved application of the already existing compounds. View Full-Text
Keywords: cisplatin; pharmacology; mechanism of action; immunogenic cell death; RNA; toxicity cisplatin; pharmacology; mechanism of action; immunogenic cell death; RNA; toxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Theile, D. Under-Reported Aspects of Platinum Drug Pharmacology. Molecules 2017, 22, 382.

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