Next Article in Journal
Green Hydroselenation of Aryl Alkynes: Divinyl Selenides as a Precursor of Resveratrol
Next Article in Special Issue
Artesunate Enhances the Cytotoxicity of 5-Aminolevulinic Acid-Based Sonodynamic Therapy against Mouse Mammary Tumor Cells In Vitro
Previous Article in Journal
Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF)
Previous Article in Special Issue
Application of the Triazolization Reaction to Afford Dihydroartemisinin Derivatives with Anti-HIV Activity
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Molecules 2017, 22(2), 323; doi:10.3390/molecules22020323

Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa
Academic Editor: Derek J. McPhee
Received: 26 December 2016 / Revised: 10 February 2017 / Accepted: 15 February 2017 / Published: 20 February 2017
(This article belongs to the Special Issue Artemisinin: Against Malaria, Cancer and Viruses)
View Full-Text   |   Download PDF [1828 KB, uploaded 20 February 2017]   |  

Abstract

Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials. In order to enhance their therapeutic efficacy, they are incorporated onto different drug delivery systems, thus yielding improved biological outcomes. This review article is focused on the currently synthesized derivatives of artemisinin and different delivery systems used for the incorporation of artemisinin and its derivatives. View Full-Text
Keywords: artemisinin; artesunate; artemether; arteether; drug delivery systems artemisinin; artesunate; artemether; arteether; drug delivery systems
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Aderibigbe, B.A. Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives. Molecules 2017, 22, 323.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top