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Molecules 2017, 22(2), 247; doi:10.3390/molecules22020247

Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds

Centro de Ciências Naturais e Humanas—CCNH—Universidade Federal do ABC—UFABC, Av. Dos Estados 5001, 09210-180 Santo André –SP, Brazil
Academic Editor: Roman Dembinski
Received: 4 January 2017 / Revised: 26 January 2017 / Accepted: 30 January 2017 / Published: 7 February 2017
(This article belongs to the Section Organic Synthesis)

Abstract

Nuclear magnetic resonance (NMR) is a powerful tool for the elucidation of chemical structure and chiral recognition. In the last decade, the number of probes, media, and experiments to analyze chiral environments has rapidly increased. The evaluation of chiral molecules and systems has become a routine task in almost all NMR laboratories, allowing for the determination of molecular connectivities and the construction of spatial relationships. Among the features that improve the chiral recognition abilities by NMR is the application of different nuclei. The simplicity of the multinuclear NMR spectra relative to 1H, the minimal influence of the experimental conditions, and the larger shift dispersion make these nuclei especially suitable for NMR analysis. Herein, the recent advances in multinuclear (19F, 31P, 13C, and 77Se) NMR spectroscopy for chiral recognition of organic compounds are presented. The review describes new chiral derivatizing agents and chiral solvating agents used for stereodiscrimination and the assignment of the absolute configuration of small organic compounds. View Full-Text
Keywords: chiral recognition; NMR spectroscopy; chirality; multinuclear; enantiopurity; enantiomeric excess; stereochemistry; absolute configuration chiral recognition; NMR spectroscopy; chirality; multinuclear; enantiopurity; enantiomeric excess; stereochemistry; absolute configuration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Silva, M.S. Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds. Molecules 2017, 22, 247.

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