Next Article in Journal
Immobilized Lipases on Functionalized Silica Particles as Potential Biocatalysts for the Synthesis of Fructose Oleate in an Organic Solvent/Water System
Next Article in Special Issue
Disparate Effects of Stilbenoid Polyphenols on Hypertrophic Cardiomyocytes In Vitro vs. in the Spontaneously Hypertensive Heart Failure Rat
Previous Article in Journal
Cytotoxic Compounds Derived from Marine Sponges. A Review (2010–2012)
Previous Article in Special Issue
Grape Polyphenols’ Effects in Human Cardiovascular Diseases and Diabetes
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Molecules 2017, 22(2), 209; doi:10.3390/molecules22020209

Actions of Quercetin, a Polyphenol, on Blood Pressure

Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Department of Bio-Ionomics, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Japan Institute for Food Education and Health, St. Agnes’ University, Kyoto 602-8013, Japan
Department of Dental Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Saisei Mirai Clinics, Moriguchi 570-0012, Japan
Author to whom correspondence should be addressed.
Academic Editor: Rosa M. Lamuela-Raventós
Received: 1 December 2016 / Revised: 23 January 2017 / Accepted: 24 January 2017 / Published: 29 January 2017
(This article belongs to the Special Issue Polyphenols and Cardiovascular Disease)
View Full-Text   |   Download PDF [1547 KB, uploaded 6 February 2017]   |  


Disorder of blood pressure control causes serious diseases in the cardiovascular system. This review focuses on the anti-hypertensive action of quercetin, a flavonoid, which is one of the polyphenols characterized as the compounds containing large multiples of phenol structural units, by varying the values of various blood pressure regulatory factors, such as vascular compliance, peripheral vascular resistance, and total blood volume via anti-inflammatory and anti-oxidant actions. In addition to the anti-inflammatory and anti-oxidant actions of quercetin, we especially describe a novel mechanism of quercetin’s action on the cytosolic Cl concentration ([Cl]c) and novel roles of the cytosolic Cl i.e.: (1) quercetin elevates [Cl]c by activating Na+-K+-2Cl cotransporter 1 (NKCC1) in renal epithelial cells contributing to Na+ reabsorption via the epithelial Na+ channel (ENaC); (2) the quercetin-induced elevation of [Cl]c in renal epithelial cells diminishes expression of ENaC leading to a decrease in renal Na+ reabsorption; and (3) this reduction of ENaC-mediated Na+ reabsorption in renal epithelial cells drops volume-dependent elevated blood pressure. In this review, we introduce novel, unique mechanisms of quercetin’s anti-hypertensive action via activation of NKCC1 in detail. View Full-Text
Keywords: flavonoid; quercetin; Na+-K+-2Cl cotransporter 1; epithelial Na+ channel; cytosolic Cl concentration flavonoid; quercetin; Na+-K+-2Cl cotransporter 1; epithelial Na+ channel; cytosolic Cl concentration

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Marunaka, Y.; Marunaka, R.; Sun, H.; Yamamoto, T.; Kanamura, N.; Inui, T.; Taruno, A. Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules 2017, 22, 209.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top