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Molecules 2017, 22(2), 209; doi:10.3390/molecules22020209

Actions of Quercetin, a Polyphenol, on Blood Pressure

1
Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
2
Department of Bio-Ionomics, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
3
Japan Institute for Food Education and Health, St. Agnes’ University, Kyoto 602-8013, Japan
4
Department of Dental Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
5
Saisei Mirai Clinics, Moriguchi 570-0012, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Rosa M. Lamuela-Raventós
Received: 1 December 2016 / Revised: 23 January 2017 / Accepted: 24 January 2017 / Published: 29 January 2017
(This article belongs to the Special Issue Polyphenols and Cardiovascular Disease)
View Full-Text   |   Download PDF [1547 KB, uploaded 6 February 2017]   |  

Abstract

Disorder of blood pressure control causes serious diseases in the cardiovascular system. This review focuses on the anti-hypertensive action of quercetin, a flavonoid, which is one of the polyphenols characterized as the compounds containing large multiples of phenol structural units, by varying the values of various blood pressure regulatory factors, such as vascular compliance, peripheral vascular resistance, and total blood volume via anti-inflammatory and anti-oxidant actions. In addition to the anti-inflammatory and anti-oxidant actions of quercetin, we especially describe a novel mechanism of quercetin’s action on the cytosolic Cl concentration ([Cl]c) and novel roles of the cytosolic Cl i.e.: (1) quercetin elevates [Cl]c by activating Na+-K+-2Cl cotransporter 1 (NKCC1) in renal epithelial cells contributing to Na+ reabsorption via the epithelial Na+ channel (ENaC); (2) the quercetin-induced elevation of [Cl]c in renal epithelial cells diminishes expression of ENaC leading to a decrease in renal Na+ reabsorption; and (3) this reduction of ENaC-mediated Na+ reabsorption in renal epithelial cells drops volume-dependent elevated blood pressure. In this review, we introduce novel, unique mechanisms of quercetin’s anti-hypertensive action via activation of NKCC1 in detail. View Full-Text
Keywords: flavonoid; quercetin; Na+-K+-2Cl cotransporter 1; epithelial Na+ channel; cytosolic Cl concentration flavonoid; quercetin; Na+-K+-2Cl cotransporter 1; epithelial Na+ channel; cytosolic Cl concentration
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Marunaka, Y.; Marunaka, R.; Sun, H.; Yamamoto, T.; Kanamura, N.; Inui, T.; Taruno, A. Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules 2017, 22, 209.

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