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Molecules 2017, 22(2), 206; doi:10.3390/molecules22020206

Hyperuricaemia, Xanthine Oxidoreductase and Ribosome‐Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research

Department of Experimental, Diagnostic and Specialty Medicine‐DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
These authors contributed equally to this paper.
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Author to whom correspondence should be addressed.
Academic Editor: Els Van Damme
Received: 30 December 2016 / Revised: 16 January 2017 / Accepted: 23 January 2017 / Published: 27 January 2017
View Full-Text   |   Download PDF [247 KB, uploaded 6 February 2017]

Abstract

The enzymes called ribosome‐inactivating proteins (RIPs) that are able to depurinate nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline research field, mostly because of their promising medical applications. The contributions of Stirpe to the development of these studies has been one of the most relevant. After a short biographical introduction, an overview is offered of the main results obtained by his investigations during last 55 years on his main research lines: hyperuricaemia, xanthine oxidoreductase and RIPs. View Full-Text
Keywords: gout; hyperuricaemia; immunotoxins; ribosome‐inactivating proteins; ricin; toxic lectins;  xanthine oxidoreductase gout; hyperuricaemia; immunotoxins; ribosome‐inactivating proteins; ricin; toxic lectins;  xanthine oxidoreductase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bolognesi, A.; Bortolotti, M.; Battelli, M.G.; Polito, L. Hyperuricaemia, Xanthine Oxidoreductase and Ribosome‐Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research. Molecules 2017, 22, 206.

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