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Molecules 2017, 22(2), 193; doi:10.3390/molecules22020193

Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers

1
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China
2
Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Nanning 530008, Guangxi, China
*
Author to whom correspondence should be addressed.
Academic Editor: Panayiotis A. Koutentis
Received: 24 December 2016 / Revised: 21 January 2017 / Accepted: 21 January 2017 / Published: 24 January 2017
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [395 KB, uploaded 24 January 2017]   |  

Abstract

A series of novel myrtenal derivatives bearing 1,2,4-triazole moiety were designed and synthesized by multi-step reactions in an attempt to develop potent antifungal agents. Their structures were confirmed by using UV-vis, FTIR, NMR, and ESI-MS analysis. Antifungal activity of the target compounds was preliminarily evaluated by the in vitro method against Fusarium oxysporum f. sp. cucumerinum, Physalospora piricola, Alternaria solani, Cercospora arachidicola, and Gibberella zeae at 50 µg/mL. Compounds 6c (R = i-Pr), 6l (R = o-NO2 Bn), and 6a (R = Et) exhibited excellent antifungal activity against P. piricola with inhibition rates of 98.2%, 96.4%, and 90.7%, respectively, showing better or comparable antifungal activity than that of the commercial fungicide azoxystrobin with a 96.0% inhibition rate, which served as a positive control. View Full-Text
Keywords: α-pinene; myrtenal; 1,2,4-triazole-thioether; antifungal activity α-pinene; myrtenal; 1,2,4-triazole-thioether; antifungal activity
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Lin, G.-S.; Duan, W.-G.; Yang, L.-X.; Huang, M.; Lei, F.-H. Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers. Molecules 2017, 22, 193.

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