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Molecules 2017, 22(12), 2215; doi:10.3390/molecules22122215

Development of Houttuynia cordata Extract-Loaded Solid Lipid Nanoparticles for Oral Delivery: High Drug Loading Efficiency and Controlled Release

1
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea
2
Wissen Co., Ltd., #410 Bio Venture Town, 461-8, Daejeon 305-811, Korea
3
College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea
4
College of Pharmacy, Pusan National University, 63 Busandaehak-ro, Geumjeong-gu, Busan 609-735, Korea
5
College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 5 December 2017 / Accepted: 12 December 2017 / Published: 13 December 2017
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Abstract

Houttuynia cordata (H. cordata) has been used for diuresis and detoxification in folk medicine as well as a herbal medicine with antiviral and antibacterial activities. H. cordata extract-loaded solid lipid nanoparticles (H-SLNs) were prepared with various concentration of poloxamer 188 or poloxamer 407 by a hot homogenization and ultrasonication method. H-SLNs dispersion was freeze-dried with or without trehalose as a cryoprotectant. The physicochemical characteristics of H-SLNs were evaluated by dynamic laser scattering (DLS), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Additionally, the in vitro release and in vitro cytotoxicity of H-SLNs were measured. Encapsulation efficiencies of H-SLNs (as quercitrin) were 92.9–95.9%. The SEM images of H-SLNs showed that H-SLNs have a spherical morphology. DSC and FT-IR showed that there were no interactions between ingredients. The increased extent of particle size of freeze-dried H-SLNs with trehalose was significantly lower than that of H-SLNs without trehalose. H-SLNs provided sustained release of quercitrin from H. cordata extracts. Cell viability of Caco-2 cells was over 70% according to the concentration of various formulation. Therefore, it was suggested that SLNs could be good carrier for administering H. cordata extracts. View Full-Text
Keywords: Houttuynia cordata; quercitrin; solid lipid nanoparticles; sustained release; poloxamer Houttuynia cordata; quercitrin; solid lipid nanoparticles; sustained release; poloxamer
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Kim, J.-H.; Baek, J.-S.; Park, J.-K.; Lee, B.-J.; Kim, M.-S.; Hwang, S.-J.; Lee, J.-Y.; Cho, C.-W. Development of Houttuynia cordata Extract-Loaded Solid Lipid Nanoparticles for Oral Delivery: High Drug Loading Efficiency and Controlled Release. Molecules 2017, 22, 2215.

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