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Molecules 2017, 22(12), 2176; doi:10.3390/molecules22122176

Chemical Constituents from Euphorbia kansui

1
Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
College of Pharmacy and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi’an 712046, China
*
Author to whom correspondence should be addressed.
Received: 30 October 2017 / Revised: 1 December 2017 / Accepted: 4 December 2017 / Published: 8 December 2017
(This article belongs to the Collection Natural Products: Anticancer Potential and Beyond)
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Abstract

In this research, a new triterpenoid, tirucalla-8,24-diene-3β,11β-diol-7-one (1), and eupha-8,24-diene-3β,11β-diol-7-one (2), which was isolated from Euphorbia kansui for the first time, together with twelve other known compounds (314), were isolated from the ethyl acetate extract of Euphorbia kansui. Their structures were elucidated based on High resolution electrospray ionization mass spectrometry (HR-ESI-MS), Infrared Spectroscopy (IR), 1D and 2D Nuclear Magnetic Resonance (NMR) data. Both constituents 1 and 2 exhibited moderate cytotoxicity against colon cancer HCT-116, gastric cancer MKN-45 and breast cancer MCF-7. View Full-Text
Keywords: Euphane and Tirucallane; triterpenes; cytotoxicity; Euphorbia kansui Euphane and Tirucallane; triterpenes; cytotoxicity; Euphorbia kansui
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Zhang, Q.; Zhou, Q.-R.; Lou, J.-W.; Chen, P.-D.; Yao, W.-F.; Tao, W.-W.; Tang, Y.-P.; Dai, G.-C.; Wang, K.; Zhang, L. Chemical Constituents from Euphorbia kansui. Molecules 2017, 22, 2176.

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