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Molecules 2017, 22(12), 2047; doi:10.3390/molecules22122047

Study on the Anticoagulant or Procoagulant Activities of Type II Phenolic Acid Derivatives

1
School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxue Road, Nanning 530004, Guangxi, China
2
Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development, Guangxi University, 100 Daxue Road, Nanning 530004, Guangxi, China
3
School of Resources, Environment, and Materials, Guangxi University, 100 Daxue Road, Nanning 530004, Guangxi, China
*
Author to whom correspondence should be addressed.
Received: 20 September 2017 / Revised: 13 November 2017 / Accepted: 21 November 2017 / Published: 28 November 2017
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Abstract

In this study, three type II phenolic acids (caffeic acid, p-hydroxycinnamic acid, and ferulic acid) were used to synthesize a total of 18 phenolic acid derivatives. With molecular docking for molecule design and target protein (factors) screening, in combination with the confirmation of target proteins (factors) by surface plasmon resonance, and the evaluation of haemostatic and anticoagulant activities with five blood assays (plasma recalcification time, prothrombin time, activated partial thromboplastin time, fibrinogen, and thrombin time), the data indicated that caffeic acid derivatives showed certain anticoagulant or procoagulant activities and that two other series contained compounds with the best anticoagulant activities. Using Materials Studio analysis, particular functional groups that affect anticoagulant or procoagulant activities were revealed, and these conclusions can guide the discovery of compounds with better activities. View Full-Text
Keywords: anticoagulant; procoagulant; haemostatic; phenolic acid; surface plasmon resonance anticoagulant; procoagulant; haemostatic; phenolic acid; surface plasmon resonance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Luo, X.; Du, C.; Cheng, H.; Chen, J.-H.; Lin, C. Study on the Anticoagulant or Procoagulant Activities of Type II Phenolic Acid Derivatives. Molecules 2017, 22, 2047.

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