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Molecules 2017, 22(12), 1947; doi:10.3390/molecules22121947

A Novel Method to Improve the Anticancer Activity of Natural-Based Hydroxyapatite against the Liver Cancer Cell Line HepG2 Using Mesoporous Magnesia as a Micro-Carrier

1
Department of Chemistry, Science College, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia
2
Department of Biology, Science College, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 30 October 2017 / Accepted: 8 November 2017 / Published: 24 November 2017
(This article belongs to the Special Issue New Drug Delivery System)
View Full-Text   |   Download PDF [2951 KB, uploaded 24 November 2017]   |  

Abstract

Micro-carriers are the best known vehicles to transport different kinds of drugs to achieve high impact. In this study, mesoporous magnesium oxide has been harnessed as a micro-carrier to encapsulate the anticancer candidate drug natural-based cubic hydroxyapatite (HAP). HAP@MgO composites with different HAP loading (0–60 wt %), were prepared by a hydrothermal treatment method using triethanol amine as a template. The characterization of the prepared composites were achieved by using XRD, Raman spectroscopy, FTIR and SEM. Characterization data confirm the formation of sphere-like structures of MgO containing HAP particles. It was observed that the size of the spheres increased with HAP loading up to 40 wt %, then collapsed. Furthermore, the anticancer property of the prepared composites was evaluated against the HepG2 liver cancer cell line. The HAP@MgO composites exhibited higher activity than neat MgO or HAP. The 20 wt % of HAP was the optimum loading to control cell proliferation by inducing apoptosis. Apoptosis was determined by typical apoptotic bodies produced by the cell membrane. View Full-Text
Keywords: HAP@MgO; cytotoxicity; HepG2; liver cancer; micro-carriers HAP@MgO; cytotoxicity; HepG2; liver cancer; micro-carriers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Awwad, N.S.; Alshahrani, A.M.; Saleh, K.A.; Hamdy, M.S. A Novel Method to Improve the Anticancer Activity of Natural-Based Hydroxyapatite against the Liver Cancer Cell Line HepG2 Using Mesoporous Magnesia as a Micro-Carrier. Molecules 2017, 22, 1947.

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