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Molecules 2017, 22(11), 1981; doi:10.3390/molecules22111981

Oleanane-Type Saponins from the Roots of Ligulariopsis shichuana and Their α-Glucosidase Inhibitory Activities

1
College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
2
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
*
Author to whom correspondence should be addressed.
Received: 3 November 2017 / Revised: 12 November 2017 / Accepted: 13 November 2017 / Published: 17 November 2017
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Abstract

Five new oleanane-type saponins, named ligushicosides A-E, and three known oleanane-type saponins were isolated from the roots of Ligulariopsis shichuana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects and exhibited potent inhibition against α-glucosidase, while compounds 1 and 2 showed excellent inhibitory activities. The 3-O-glycoside moiety in oleanane-type saponin is important for the α-glucosidase inhibitory effects. View Full-Text
Keywords: Ligulariopsis shichuana; oleanane-type saponins; α-glucosidase inhibitory Ligulariopsis shichuana; oleanane-type saponins; α-glucosidase inhibitory
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Wu, H.-B.; Liu, T.-T.; Wang, W.-S.; Feng, J.-C.; Tian, H.-M. Oleanane-Type Saponins from the Roots of Ligulariopsis shichuana and Their α-Glucosidase Inhibitory Activities. Molecules 2017, 22, 1981.

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