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Molecules 2017, 22(11), 1946; doi:10.3390/molecules22111946

Early Response Monitoring Following Radiation Therapy by Using [18F]FDG and [11C]Acetate PET in Prostate Cancer Xenograft Model with Metabolomics Corroboration

1
Center for Advanced Molecular Imaging and Translation (CAMIT), Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
2
Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
3
Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
4
Imaging Core Lab, Department of Medical Imaging and Intervention, Institute for Radiological Research, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Linkou Medical Center, 5 Fuhsing Street, Guishan, Taoyuan 333, Taiwan
5
Clinical Metabolomics Core Lab, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 6 October 2017 / Revised: 6 November 2017 / Accepted: 8 November 2017 / Published: 10 November 2017
(This article belongs to the Special Issue Molecular Imaging and Treatment Monitoring of Cancer)
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Abstract

We aim to characterize the metabolic changes associated with early response to radiation therapy in a prostate cancer mouse model by 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) and [11C]acetate ([11C]ACT) positron emission tomography, with nuclear magnetic resonance (NMR) metabolomics corroboration. [18F]FDG and [11C]ACT PET were performed before and following irradiation (RT, 15Gy) for transgenic adenocarcinoma of mouse prostate xenografts. The underlying metabolomics alterations of tumor tissues were analyzed by using ex vivo NMR. The [18F]FDG total lesion glucose (TLG) of the tumor significant increased in the RT group at Days 1 and 3 post-irradiation, compared with the non-RT group (p < 0.05). The [11C]ACT maximum standard uptake value (SUVmax) in RT (0.83 ± 0.02) and non-RT groups (0.85 ± 0.07) were not significantly different (p > 0.05). The ex vivo NMR analysis showed a 1.70-fold increase in glucose and a 1.2-fold increase in acetate in the RT group at Day 3 post-irradiation (p < 0.05). Concordantly, the expressions of cytoplasmic acetyl-CoA synthetase in the irradiated tumors was overexpressed at Day 3 post-irradiation (p < 0.05). Therefore, TLG of [18F]FDG in vivo PET images can map early treatment response following irradiation and be a promising prognostic indicator in a longitudinal preclinical study. The underlying metabolic alterations was not reflected by the [11C]ACT PET. View Full-Text
Keywords: [11C]Acetate; cancer metabolism; 2-deoxy-2-[18F]fluoro-d-glucose; nuclear magnetic resonance; positron emission tomography; total lesion glycolysis; radiation therapy [11C]Acetate; cancer metabolism; 2-deoxy-2-[18F]fluoro-d-glucose; nuclear magnetic resonance; positron emission tomography; total lesion glycolysis; radiation therapy
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MDPI and ACS Style

Chung, Y.-H.; Tsai, C.-K.; Wang, C.-C.; Chen, H.-M.; Lu, K.-Y.; Chiu, H.; Lin, Y.-C.; Yen, T.-C.; Lin, G. Early Response Monitoring Following Radiation Therapy by Using [18F]FDG and [11C]Acetate PET in Prostate Cancer Xenograft Model with Metabolomics Corroboration. Molecules 2017, 22, 1946.

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