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Molecules 2017, 22(11), 1919; doi:10.3390/molecules22111919

Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus

1
Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, Bielefeld 33501, Germany
2
Department of Chemistry, College of Natural Sciences, Jimma University, P.O. Box 378, Jimma 251, Ethiopia
*
Authors to whom correspondence should be addressed.
Received: 7 October 2017 / Revised: 2 November 2017 / Accepted: 3 November 2017 / Published: 7 November 2017
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Four new para-benzoquinone containing abietane-type diterpenoids (14) along with thirteen known diterpenoids (517) were isolated from the roots of Plectranthus punctatus. The structures of the compounds were established by detailed spectroscopic analyses and comparison with literature data. The compounds were tested for their antibacterial and cytotoxic activity and showed significant inhibitory activity against all bacterial strains used, with compounds 6, 8, 10, and 11 showing an inhibition zone for Staphylococcus warneri even greater than the reference drug, gentamycin. View Full-Text
Keywords: antibiotic; benzoquinone; ethnomedicine; diterpenoids; plant-derived natural products antibiotic; benzoquinone; ethnomedicine; diterpenoids; plant-derived natural products
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Abdissa, N.; Frese, M.; Sewald, N. Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus. Molecules 2017, 22, 1919.

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