Recent Advances in the Synthesis of Spiroheterocycles via N-Heterocyclic Carbene Organocatalysis
AbstractSpiroheterocycles are regarded as a privileged framework because of their wide distribution in various natural products and synthetic molecules and promising bioactivities. This review focuses on the recent advances in the synthesis of spiroheterocycles by using the strategy of N-heterocyclic carbene (NHC) organocatalysis, and is organized based on the stereoselectivity and the reactive intermediates. According to the stereochemistry, this review was divided into two main parts, covering racemic and enantioselective versions. In each part, we firstly describe the synthetic transformations using nucleophilic Breslow intermediates, and then discuss the reactions that employ electrophilic acylazolium or radical cation intermediates. With those distinct catalytic activation modes of NHC organocatlysis, we expect this synthetic protocol will possibly produce new molecules with structural novelty and complexity, which may warrant further research in the field of drug discovery. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Liu, Y.; Zhang, X.; Zeng, R.; Zhang, Y.; Dai, Q.-S.; Leng, H.-J.; Gou, X.-J.; Li, J.-L. Recent Advances in the Synthesis of Spiroheterocycles via N-Heterocyclic Carbene Organocatalysis. Molecules 2017, 22, 1882.
Liu Y, Zhang X, Zeng R, Zhang Y, Dai Q-S, Leng H-J, Gou X-J, Li J-L. Recent Advances in the Synthesis of Spiroheterocycles via N-Heterocyclic Carbene Organocatalysis. Molecules. 2017; 22(11):1882.Chicago/Turabian Style
Liu, Yue; Zhang, Xiang; Zeng, Rong; Zhang, Ying; Dai, Qing-Song; Leng, Hai-Jun; Gou, Xiao-Jun; Li, Jun-Long. 2017. "Recent Advances in the Synthesis of Spiroheterocycles via N-Heterocyclic Carbene Organocatalysis." Molecules 22, no. 11: 1882.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.