Next Article in Journal
Sustainable Bio-Based Phenol-Formaldehyde Resoles Using Hydrolytically Depolymerized Kraft Lignin
Previous Article in Journal
The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot
Previous Article in Special Issue
Margination of Fluorescent Polylactic Acid–Polyaspartamide based Nanoparticles in Microcapillaries In Vitro: the Effect of Hematocrit and Pressure
Article Menu

Export Article

Open AccessArticle
Molecules 2017, 22(11), 1852; doi:10.3390/molecules22111852

Biological Properties of Low-Toxic PLGA and PLGA/PHB Fibrous Nanocomposite Scaffolds for Osseous Tissue Regeneration. Evaluation of Potential Bioactivity

1
Department of Experimental Surgery and Biomaterials Research, Wrocław Medical University, Pasteura 1, 50-367 Wrocław, Poland
2
Department of Material and Commodity Sciences and Textile Metrology, Technical University of Lodz, Zeromskiego 116, 90-924 Lodz, Poland
3
Department of General Radiology, Interventional Radiology and Neuroradiology, Wrocław Medical University, Pasteura 1, 50-367 Wrocław, Poland
*
Author to whom correspondence should be addressed.
Received: 5 September 2017 / Revised: 19 October 2017 / Accepted: 24 October 2017 / Published: 28 October 2017
(This article belongs to the Special Issue Biomedical Applications of Polylactide (PLA) and its Copolymers)

Abstract

Abstracts: The aim of the study was to evaluate the biocompatibility and bioactivity of two new prototype implants for bone tissue regeneration made from biodegradable fibrous materials. The first is a newly developed poly(l-lactide-co-glycolide), (PLGA), and the second is a blend of PLGA with synthetic poly([R,S]-3-hydroxybutyrate) (PLGA/PHB). The implant prototypes comprise PLGA or PLGA/PHB nonwoven fabrics with designed pore structures to create the best conditions for cell proliferation. The bioactivity of the proposed implants was enhanced by introducing a hydroxyapatite material and a biologically active agent, namely, growth factor IGF1, encapsulated in calcium alginate microspheres. To assess the biocompatibility and bioactivity, allergenic tests and an assessment of the local reaction of bone tissue after implantation were performed. Comparative studies of local tissue response after implantation into trochanters for a period of 12 months were performed on New Zealand rabbits. Based on the results of the in vivo evaluation of the allergenic effects and the local tissue reaction 12 months after implantation, it was concluded that the two implant prototypes, PLGA + IGF1 and PLGA/PHB + IGF1, were characterized by high biocompatibility with the soft and bone tissues of the tested animals. View Full-Text
Keywords: biocompatibility; bioresorption; nonwoven fabrics; bone implant; poly(l-lactide-co-glycolide); synthetic poly([R,S]-3-hydroxybutyrate); encapsulated growth factor biocompatibility; bioresorption; nonwoven fabrics; bone implant; poly(l-lactide-co-glycolide); synthetic poly([R,S]-3-hydroxybutyrate); encapsulated growth factor
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Żywicka, B.; Krucińska, I.; Garcarek, J.; Szymonowicz, M.; Komisarczyk, A.; Rybak, Z. Biological Properties of Low-Toxic PLGA and PLGA/PHB Fibrous Nanocomposite Scaffolds for Osseous Tissue Regeneration. Evaluation of Potential Bioactivity. Molecules 2017, 22, 1852.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top