Stereopermutation on the Putative Structure of the Marine Natural Product Mucosin
AbstractA stereodivergent total synthesis has been executed based on the plausibly misassigned structure of the unusual marine hydrindane mucosin (1). The topological connectivity of the four contiguous all-carbon stereocenters has been examined by selective permutation on the highlighted core. Thus, capitalizing on an unprecedented stereofacial preference of the cis-fused bicycle[4.3.0]non-3-ene system when a Michael acceptor motif is incorporated, copper-mediated conjugate addition furnished a single diastereomer. Cued by the relative relationship reported for the appendices in the natural product, the resulting anti-adduct was elaborated into a probative target structure 1*. View Full-Text
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Antonsen, S.G.; Gallantree-Smith, H.; Görbitz, C.H.; Hansen, T.V.; Stenstrøm, Y.H.; Nolsøe, J.M.J. Stereopermutation on the Putative Structure of the Marine Natural Product Mucosin. Molecules 2017, 22, 1720.
Antonsen SG, Gallantree-Smith H, Görbitz CH, Hansen TV, Stenstrøm YH, Nolsøe JMJ. Stereopermutation on the Putative Structure of the Marine Natural Product Mucosin. Molecules. 2017; 22(10):1720.Chicago/Turabian Style
Antonsen, Simen G.; Gallantree-Smith, Harrison; Görbitz, Carl H.; Hansen, Trond V.; Stenstrøm, Yngve H.; Nolsøe, Jens M.J. 2017. "Stereopermutation on the Putative Structure of the Marine Natural Product Mucosin." Molecules 22, no. 10: 1720.
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