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Molecules 2017, 22(10), 1639; doi:10.3390/molecules22101639

N-(4-bromophenethyl) Caffeamide Protects Skin from UVB-Induced Inflammation Through MAPK/IL-6/NF-κB-Dependent Signaling in Human Skin Fibroblasts and Hairless Mouse Skin

1
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
2
Department of Biotechnology, Asia University, Taichung 413, Taiwan
3
Department of Dermatology, China Medical University Hospital, Taichung 404, Taiwan
4
School of Medicine, China Medical University, Taichung 404, Taiwan
5
Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan
These two authors contribute equally to this work.
*
Author to whom correspondence should be addressed.
Received: 4 August 2017 / Revised: 26 September 2017 / Accepted: 26 September 2017 / Published: 29 September 2017
(This article belongs to the Special Issue Anti-inflammatory Agents)
View Full-Text   |   Download PDF [5665 KB, uploaded 29 September 2017]   |  

Abstract

Long-term exposure to ultraviolet (UV) irradiation causes skin inflammation and aging. N-(4-bromophenethyl) caffeamide (K36H) possesses antioxidant and antimelanogenic properties. The present study investigated the effects of K36H on UVB-induced skin inflammation in human skin fibroblasts and hairless mice and evaluated the underlying mechanisms. The in vitro results indicated that K36H reduced UVB-induced mitogen-activated protein kinase (MAP kinase) expression. Furthermore, K36H treatment reduced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) protein expression in UVB-irradiated fibroblasts by regulating IκB and nuclear factor-kappa B (NF-κB) expression. In the animal study, topically applied K36H markedly reduced inflammation and skin thickness and prevented photodamage to the skin of hairless mice. In addition, K36H inhibited the levels of UV-upregulated inflammation-related proteins levels such as IL-1, iNOS, and NF-κB in the dermis of hairless mice. Our findings demonstrated the antioxidant and anti-inflammatory properties of K36H in human skin fibroblasts and hairless mice. Therefore, K36H can be developed as an antiphotodamage and antiphotoinflammation agent. View Full-Text
Keywords: N-(4-bromophenethyl) caffeamide; photoinflammation; propolis; IL-6; NF-κB N-(4-bromophenethyl) caffeamide; photoinflammation; propolis; IL-6; NF-κB
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kuo, Y.-H.; Wu, P.-Y.; Chen, C.-W.; Lin, P.; Wen, K.-C.; Lin, C.-Y.; Chiang, H.-M. N-(4-bromophenethyl) Caffeamide Protects Skin from UVB-Induced Inflammation Through MAPK/IL-6/NF-κB-Dependent Signaling in Human Skin Fibroblasts and Hairless Mouse Skin. Molecules 2017, 22, 1639.

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