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Molecules 2017, 22(10), 1617; doi:10.3390/molecules22101617

A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae

1
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China
2
Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China
3
Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, China
4
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 55500, China
5
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650000, China
These authors contribute equally to this work.
*
Author to whom correspondence should be addressed.
Received: 17 August 2017 / Accepted: 17 September 2017 / Published: 28 September 2017
View Full-Text   |   Download PDF [814 KB, uploaded 28 September 2017]   |  

Abstract

Fructus schisandrae (Wuweizi in Chinese), a common traditional Chinese herbal medicine, has been used for centuries to treat chronic liver disease. The therapeutic efficacy of Wuweizi has also been validated in clinical practice. In this study, molecular docking and network analysis were carried out to explore the hepatoprotective mechanism of Wuweizi as an effective therapeutic approach to treat liver disease. Multiple active compounds of Wuweizi were docked with 44 protein targets related with viral hepatitis, fatty liver, liver fibrosis, cirrhosis, and liver cancer. A compound–target network was constructed through network pharmacology analysis, predicting the relationships of active ingredients to the targets. Our results demonstrated that schisantherin, schisandrin B, schisandrol B, kadsurin, Wuweizisu C, Gomisin A, Gomisin G, and angeloylgomisin may target with 21 intracellular proteins associated with liver diseases, especially with fatty liver disease. The CYP2E1, PPARα, and AMPK genes and their related pathway may play a pivotal role in the hepatoprotective effects of Wuweizi. The network pharmacology strategy used provides a forceful tool for searching the action mechanism of traditional herbal medicines and novel bioactive ingredients. View Full-Text
Keywords: Wuweizi; network pharmacology; hepatoprotective effect Wuweizi; network pharmacology; hepatoprotective effect
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Hong, M.; Zhang, Y.; Li, S.; Tan, H.Y.; Wang, N.; Mu, S.; Hao, X.; Feng, Y. A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae. Molecules 2017, 22, 1617.

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