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Molecules 2017, 22(10), 1601; doi:10.3390/molecules22101601

Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines

Department of Applied Chemistry, College of Science, Northeast Agricultural University, Harbin 150030, China
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Author to whom correspondence should be addressed.
Received: 19 August 2017 / Revised: 21 September 2017 / Accepted: 21 September 2017 / Published: 22 September 2017
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, 1H-NMR, 13C-NMR, HRMS. The biological activity tests indicated the compounds could protect maize against the injury caused by chlorsulfuron to some extent. The molecular docking result showed that the new compound competed with chlorsulfuron to bind with the herbicide target enzyme active site to attain detoxification. View Full-Text
Keywords: active subunit combination; sulfonylurea benzothiazoline; solvent-free synthesis; safener activity active subunit combination; sulfonylurea benzothiazoline; solvent-free synthesis; safener activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fu, Y.; Wang, J.-Y.; Zhang, D.; Chen, Y.-F.; Gao, S.; Zhao, L.-X.; Ye, F. Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines. Molecules 2017, 22, 1601.

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