Next Article in Journal
N-Halamine Biocidal Materials with Superior Antimicrobial Efficacies for Wound Dressings
Next Article in Special Issue
Therapeutic Mechanisms of Vernonia amygdalina Delile in the Treatment of Prostate Cancer
Previous Article in Journal / Special Issue
Cytotoxic and Apoptotic Activities of Prunus spinosa Trigno Ecotype Extract on Human Cancer Cells
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(10), 1562; doi:10.3390/molecules22101562

Cytotoxic and Hypoglycemic Activity of Triterpenoid Saponins from Camellia oleifera Abel. Seed Pomace

1
College of Horticulture, Qingdao Agricultural University, Qingdao 266109, China
2
College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China
3
State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, China
*
Author to whom correspondence should be addressed.
Received: 19 July 2017 / Revised: 14 September 2017 / Accepted: 15 September 2017 / Published: 21 September 2017
(This article belongs to the Special Issue Natural Products: Anticancer Potential and Beyond)
View Full-Text   |   Download PDF [1108 KB, uploaded 21 September 2017]   |  

Abstract

One new and three known triterpenoid saponins were isolated and identified from Camellia oleifera seeds through IR, NMR, HR-ESI-MS and GC-MS spectroscopic methods, namely oleiferasaponin A3, oleiferasaponin A1, camelliasaponin B1, and camelliasaponin B2. The structure of oleiferasaponin A3 was elucidated as 16α-hydroxy-21β-O-angeloyl-22α-O-cinnamoyl-23α-aldehyde-28-dihydroxymethylene-olean-12-ene-3β-O-[β-d-galactopyranosyl-(1→2)]-[β-d-xylopyranosyl-(1→2)-β-d-galactopyranosyl-(1→3)]-β-d-gluco-pyranosiduronic acid. Camelliasaponin B1 and camelliasaponin B2 exhibited potent cytotoxic activity on three human tumour cell lines (human lung tumour cells (A549), human liver tumour cells (HepG2), cervical tumour cells (Hela)). The hypoglycemic activity of oleiferasaponin A1 was testified by protecting pancreatic β-cell lines from high-glucose damage. View Full-Text
Keywords: Camellia oleifera; triterpenoid saponin; oleiferasaponin A3; cytotoxic activity; hypoglycemic activity Camellia oleifera; triterpenoid saponin; oleiferasaponin A3; cytotoxic activity; hypoglycemic activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Di, T.-M.; Yang, S.-L.; Du, F.-Y.; Zhao, L.; Xia, T.; Zhang, X.-F. Cytotoxic and Hypoglycemic Activity of Triterpenoid Saponins from Camellia oleifera Abel. Seed Pomace. Molecules 2017, 22, 1562.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top