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Molecules 2017, 22(1), 53; doi:10.3390/molecules22010053

Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation

Department of Biology and Environment, Zhejiang A&F University, Shaoxing 311800, Zhejiang, China
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 21 November 2016 / Revised: 22 December 2016 / Accepted: 28 December 2016 / Published: 30 December 2016
(This article belongs to the Collection Heterocyclic Compounds)
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Abstract

A tandem transformation of C-N coupling/C-H carbonylation has been developed for the synthesis of benzo-1,4-oxazepine pharmaceutically derivatives. Notably, this reaction was accomplished by various phenylamine with ally halides under carbon dioxide atmosphere employing 2-(2-dimethylamino-vinyl)-1H-inden-1-olcatalyzed. Furthermore, under the optimized conditions, various benzo-1,4-oxazepine derivatives were obtained in good yields. Finally, a plausible CuI/CuIII mechanism of C-N coupling/C-H carbonylation transformation was proposed. View Full-Text
Keywords: benzo-1,4-oxazepine; copper catalyst; tandem transformation; C-N coupling; C-H carbonylation benzo-1,4-oxazepine; copper catalyst; tandem transformation; C-N coupling; C-H carbonylation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhao, X.; Zhang, J.; Zheng, Z.; Xu, R. Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation. Molecules 2017, 22, 53.

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