Next Article in Journal
Phloretin Exerts Anti-Tuberculosis Activity and Suppresses Lung Inflammation
Next Article in Special Issue
The Effect and Mechanism of Transdermal Penetration Enhancement of Fu’s Cupping Therapy: New Physical Penetration Technology for Transdermal Administration with Traditional Chinese Medicine (TCM) Characteristics
Previous Article in Journal
Highly Efficient Enzymatic Preparation of Daidzein in Deep Eutectic Solvents
Previous Article in Special Issue
NO Exchange for a Water Molecule Favorably Changes Iontophoretic Release of Ruthenium Complexes to the Skin
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(1), 185; doi:10.3390/molecules22010185

Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators

Division de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico, Cuautitlán Izcalli 54740, Estado de Mexico, Mexico
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Yogeshvar Kalia and Derek J. McPhee
Received: 16 September 2016 / Revised: 3 January 2017 / Accepted: 17 January 2017 / Published: 22 January 2017
(This article belongs to the Special Issue Transdermal Delivery Systems: Current Landscape and Trends)
View Full-Text   |   Download PDF [1860 KB, uploaded 22 January 2017]   |  

Abstract

The absorption modulating activity of two alkylglycerol derivatives (batyl and chimyl alcohol) on skin barrier properties was evaluated. Biophysical tests such as transepidermal water loss (TEWL) and attenuated total reflectance–Fourier transform infrared (ATR-FTIR) spectroscopy, as well as in vitro skin permeation studies, were performed in order to determine the effect of these compounds as chemical absorption modulators. Four drugs were used as models: three NSAIDS (diclofenac, naproxen, and piroxicam) and glycyrrhizic acid. The results showed that treatment of the skin with alkylglycerols caused (i) a reduction on the amount of drug permeated; (ii) a reduction in TEWL; and (iii) changes in the ATR-FTIR peaks of stratum corneum lipids, indicative of a more ordered structure. All of these findings confirm that alkyl glycerols have an absorption retarding effect on the drugs tested. Such effects are expected to give rise to important applications in the pharmaceutical and cosmetic sectors, in cases where it is desirable for the drug to remain in the superficial layers of the skin to achieve a local effect. View Full-Text
Keywords: alkylglycerols; skin permeation; absorption modulators; absorption retarders; transepidermal water loss (TEWL); attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy alkylglycerols; skin permeation; absorption modulators; absorption retarders; transepidermal water loss (TEWL); attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bernal-Chávez, S.A.; Pérez-Carreto, L.Y.; Nava-Arzaluz, M.G.; Ganem-Rondero, A. Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators. Molecules 2017, 22, 185.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top