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Molecules 2017, 22(1), 170; doi:10.3390/molecules22010170

Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides

1
Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Monawarah 1343, Saudi Arabia
2
Photochemistry Department, National Research Centre, Dokki 12622, Giza, Egypt
3
Applied Organic Chemistry Department, National Research Centre, Dokki 12622, Giza, Egypt
4
Chemistry Department, College of Science, Aljouf University, Sakaka, Al-Jouf 72341, Saudi Arabia
5
Department of Tanning Materials and Leather Technology, National Research Centre, Dokki 12622, Giza, Egypt
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 24 December 2016 / Revised: 10 January 2017 / Accepted: 16 January 2017 / Published: 20 January 2017
View Full-Text   |   Download PDF [926 KB, uploaded 20 January 2017]   |  

Abstract

New 1-thia-azaspiro[4.5]decane derivatives, their derived thiazolopyrimidine and 1,3,4-thiadiazole compounds were synthesized. The thioglycoside derivatives of the synthesized (1,3,4-thiadiazolyl)thiaazaspiro[4.5]decane and thiazolopyrimidinethione compounds were synthesized by glycosylation reactions using acetylated glycosyl bromides. The anticancer activity of synthesized compounds was studied against the cell culture of HepG-2 (human liver hepatocellular carcinoma), PC-3 (human prostate adenocarcinoma) and HCT116 (human colorectal carcinoma) cell lines and a number of compounds showed moderate to high inhibition activities. View Full-Text
Keywords: 1-thia-azaspiro[4.5]decane; thiazolopyrimidine; thioglycosides; 1,3,4-thiadiazoles anticancer activity 1-thia-azaspiro[4.5]decane; thiazolopyrimidine; thioglycosides; 1,3,4-thiadiazoles anticancer activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Flefel, E.M.; El-Sayed, W.A.; Mohamed, A.M.; El-Sofany, W.I.; Awad, H.M. Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides. Molecules 2017, 22, 170.

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