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Molecules 2017, 22(1), 134; doi:10.3390/molecules22010134

Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders

Department of Rheumatology and Immunology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
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Academic Editor: Chun Kwok Wong
Received: 12 December 2016 / Revised: 5 January 2017 / Accepted: 10 January 2017 / Published: 14 January 2017
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Abstract

A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the pro-inflammatory Th17 side is hence suspected to contribute to exacerbation of autoimmune disorders. This review aims to summarize recent data and advances in targeted therapeutic modification of the Th17/Treg-balance, as well as information on the efficacy of candidate therapeutics with respect to the treatment of autoimmune diseases. View Full-Text
Keywords: Th17-cells; regulatory T-cells; autoimmunity; RORγt; Foxp3 Th17-cells; regulatory T-cells; autoimmunity; RORγt; Foxp3
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Fasching, P.; Stradner, M.; Graninger, W.; Dejaco, C.; Fessler, J. Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders. Molecules 2017, 22, 134.

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