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Molecules 2016, 21(9), 1250; doi:10.3390/molecules21091250

Two New Clerodane Diterpenes from Tinospora sagittata

1,†
,
1,2,†
,
1,3
and
1,2,*
1
College of Plant Protection, Hunan Agricultural University, Changsha 410128, China
2
Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China
3
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 24 August 2016 / Revised: 16 September 2016 / Accepted: 16 September 2016 / Published: 19 September 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [932 KB, uploaded 19 September 2016]   |  

Abstract

Two new clerodane-type diterpenes, tinosporins C (1) and tinosporins D (2) were isolated from the stems of Tinospora sagittata (Oliv.), together with three known ones, columbin (3), tinophylloloside (4), and tinospinoside D (5). The structures of these compounds were determined on the basis of spectroscopic data interpretation, with that of the absolute configuration of compound 1 was assigned by experimental and calculated ECD spectra. The cytotoxicity and α-glucosidase inhibitory activities of isolated compounds were evaluated in vitro. View Full-Text
Keywords: Tinospora sagittata; clerodane diterpenes; α-glucosidase inhibitory activity Tinospora sagittata; clerodane diterpenes; α-glucosidase inhibitory activity
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Li, G.; Ding, W.; Wan, F.; Li, Y. Two New Clerodane Diterpenes from Tinospora sagittata. Molecules 2016, 21, 1250.

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