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Molecules 2016, 21(9), 1223; doi:10.3390/molecules21091223

Synergistic Antipseudomonal Effects of Synthetic Peptide AMP38 and Carbapenems

1
Molecular Microbiology and Antibiotics, Department of Pathology and Experimental Therapeutics, Medical School-IDIBELL, University of Barcelona, Hospitalet, Barcelona 08907, Spain
2
Department of Public Health, Mental Health and Perinatal Nursing, US of Nursing, University of Barcelona, Hospitalet, Barcelona 08907, Spain
3
Department of Physical Chemistry and Institute of Nanoscience and Nanotechnology, University of Barcelona, Barcelona 08028, Spain
4
Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain
5
Cooperativa De Ensino Superior Politécnico Universitário, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (CESPU, IINFACTS), Gandra 4585-116, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 28 July 2016 / Revised: 7 September 2016 / Accepted: 9 September 2016 / Published: 12 September 2016
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Abstract

The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem. View Full-Text
Keywords: Pseudomonas; antimicrobial peptides; synergism; biofilm eradication Pseudomonas; antimicrobial peptides; synergism; biofilm eradication
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MDPI and ACS Style

Rudilla, H.; Fusté, E.; Cajal, Y.; Rabanal, F.; Vinuesa, T.; Viñas, M. Synergistic Antipseudomonal Effects of Synthetic Peptide AMP38 and Carbapenems. Molecules 2016, 21, 1223.

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