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Molecules 2016, 21(9), 1223; doi:10.3390/molecules21091223

Synergistic Antipseudomonal Effects of Synthetic Peptide AMP38 and Carbapenems

Molecular Microbiology and Antibiotics, Department of Pathology and Experimental Therapeutics, Medical School-IDIBELL, University of Barcelona, Hospitalet, Barcelona 08907, Spain
Department of Public Health, Mental Health and Perinatal Nursing, US of Nursing, University of Barcelona, Hospitalet, Barcelona 08907, Spain
Department of Physical Chemistry and Institute of Nanoscience and Nanotechnology, University of Barcelona, Barcelona 08028, Spain
Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain
Cooperativa De Ensino Superior Politécnico Universitário, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (CESPU, IINFACTS), Gandra 4585-116, Portugal
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 28 July 2016 / Revised: 7 September 2016 / Accepted: 9 September 2016 / Published: 12 September 2016
View Full-Text   |   Download PDF [1003 KB, uploaded 12 September 2016]   |  


The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem. View Full-Text
Keywords: Pseudomonas; antimicrobial peptides; synergism; biofilm eradication Pseudomonas; antimicrobial peptides; synergism; biofilm eradication

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rudilla, H.; Fusté, E.; Cajal, Y.; Rabanal, F.; Vinuesa, T.; Viñas, M. Synergistic Antipseudomonal Effects of Synthetic Peptide AMP38 and Carbapenems. Molecules 2016, 21, 1223.

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