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Molecules 2016, 21(9), 1174; doi:10.3390/molecules21091174

Recent Advances in Recoverable Systems for the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction (CuAAC)

Dipartimento di Chimica e Chimica Industriale Università di Pisa, Via G. Moruzzi 13, Pisa 56124, Italy
ISTM-CNR, Via C. Golgi 19, Milano 20133, Italy
Academic Editor: Maurizio Benaglia
Received: 1 August 2016 / Revised: 26 August 2016 / Accepted: 30 August 2016 / Published: 5 September 2016
(This article belongs to the Special Issue Recent Advancements in Polymer-Supported Catalysis)


The explosively-growing applications of the Cu-catalyzed Huisgen 1,3-dipolar cycloaddition reaction between organic azides and alkynes (CuAAC) have stimulated an impressive number of reports, in the last years, focusing on recoverable variants of the homogeneous or quasi-homogeneous catalysts. Recent advances in the field are reviewed, with particular emphasis on systems immobilized onto polymeric organic or inorganic supports. View Full-Text
Keywords: supported catalysts; click-chemistry; continuous-flow chemistry; 1,2,3-triazoles supported catalysts; click-chemistry; continuous-flow chemistry; 1,2,3-triazoles

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mandoli, A. Recent Advances in Recoverable Systems for the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction (CuAAC). Molecules 2016, 21, 1174.

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