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Molecules 2016, 21(9), 1130; doi:10.3390/molecules21091130

Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.

1
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China
2
Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, Jiangsu, China
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 24 July 2016 / Revised: 24 August 2016 / Accepted: 24 August 2016 / Published: 2 September 2016
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [1033 KB, uploaded 2 September 2016]   |  

Abstract

The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 217 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 ± 0.01 µM), 2,4,2′,4′-tetrahydroxychalcone (IC50 0.07 ± 0.02 µM), morachalcone A (IC50 0.08 ± 0.02 µM), oxyresveratrol (IC50 0.10 ± 0.01 µM), and moracin M (8.00 ± 0.22 µM) exhibited significant tyrosinase inhibition activities, much stronger than that of the positive control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents. View Full-Text
Keywords: Morus alba; twigs; phenolic compounds; tyrosinase inhibition Morus alba; twigs; phenolic compounds; tyrosinase inhibition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, L.; Tao, G.; Chen, J.; Zheng, Z.-P. Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.. Molecules 2016, 21, 1130.

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