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Molecules 2016, 21(9), 1125; doi:10.3390/molecules21091125

Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2
School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China
3
Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Vassilios Roussis and Efstathia Ioannou
Received: 19 July 2016 / Revised: 15 August 2016 / Accepted: 24 August 2016 / Published: 26 August 2016
(This article belongs to the Special Issue Triterpenes and Triterpenoids 2016)
View Full-Text   |   Download PDF [1040 KB, uploaded 26 August 2016]   |  

Abstract

Three new triterpenoid alkaloids, namely buxmicrophyllines P–R (13), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses. Structurally, compounds 13 belong to the 9,10-cycloartane type alkaloids. In addition, compound 3 exhibited moderate cytotoxic activities in vitro against HL-60, SMMC-7221, A-549, MCF-7, and SW480 cell lines (with IC50 values ranging from 4.51 to 15.58 μM). View Full-Text
Keywords: Buxus microphylla; triterpenoid alkaloid; cytotoxicity Buxus microphylla; triterpenoid alkaloid; cytotoxicity
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Bai, S.-T.; Zhu, G.-L.; Peng, X.-R.; Dong, J.-R.; Yu, M.-Y.; Chen, J.-C.; Wan, L.-S.; Qiu, M.-H. Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines. Molecules 2016, 21, 1125.

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