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Molecules 2016, 21(8), 967; doi:10.3390/molecules21080967

Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives

School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK
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Academic Editor: Philippe Belmont
Received: 28 June 2016 / Revised: 19 July 2016 / Accepted: 20 July 2016 / Published: 23 July 2016
(This article belongs to the Collection Heterocyclic Compounds)
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Abstract

A simple synthetic route affording 27%–85% yields of benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring systems from readily available 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline starting materials in toluene and catalysed by p-toluene-sulfonic acid is developed. The 1H- and 13C-NMR spectra of the final products were assigned using a variety of one and two-dimensional NMR experiments. The distinction between the two potential isomers of the final products was made on the basis of heteronuclear multiple bond connectivity (HMBC) NMR spectra. View Full-Text
Keywords: diazocine; isoindole; isobenzofuran-1(3H)-ones; 2D-NMR diazocine; isoindole; isobenzofuran-1(3H)-ones; 2D-NMR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bassin, J.P.; Anagani, B.; Benham, C.; Goyal, M.; Hashemian, M.; Gerhard, U. Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives. Molecules 2016, 21, 967.

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