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Molecules 2016, 21(8), 1054; doi:10.3390/molecules21081054

Bioactive Thiazine and Benzothiazine Derivatives: Green Synthesis Methods and Their Medicinal Importance

1,2,3,* and 1,*
1
National Center of Excellence in Physical Chemistry, Peshawar University, Peshawar, Khyber Pukhtoonkhwa 25120, Pakistan
2
Department of Biochemistry, Abdul Wali Khan University Mardan, Khyber Pukhtoonkhwa 25120, Pakistan
3
Department of Chemistry, Islamia College University Peshawar, Peshawar, Khyber Pukhtoonkhwa 25120, Pakistan
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 11 July 2016 / Revised: 5 August 2016 / Accepted: 6 August 2016 / Published: 15 August 2016

Abstract

Thiazines are a group of heterocyclic organic compounds that are still largely unexplored for their pharmacological activities. There are different available methods for the synthesis of thiazine derivatives in the literature. In this review, we discuss available methods of thiazine preparation through green synthesis methods. Beside their synthesis, many thiazine derivatives are biologically active and play an important role in the treatment of various diseases and show promising results of varying degrees, where they act as antibacterial, antifungal, antitumor, antimalarial, antineoplastic, antiviral, anti-inflammatory, analgesic and anticancer agents and thus they represent an interesting class of heterocyclic medicinal compounds worthy of further exploration. View Full-Text
Keywords: thiazine; green synthesis; biologically active; antibacterial activity; anticancer agents thiazine; green synthesis; biologically active; antibacterial activity; anticancer agents
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Badshah, S.L.; Naeem, A. Bioactive Thiazine and Benzothiazine Derivatives: Green Synthesis Methods and Their Medicinal Importance. Molecules 2016, 21, 1054.

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