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Molecules 2016, 21(8), 1031; doi:10.3390/molecules21081031

New Sesquiterpenenoids from Ainsliaea yunnanensis

1
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
2
College of Chemical and Biological Engineering, Yichun University, 576 Xuefu Road, Yichun 336000, China
3
College of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China
These authors contributed equally to this paper.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 22 June 2016 / Revised: 2 August 2016 / Accepted: 3 August 2016 / Published: 8 August 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [4261 KB, uploaded 8 August 2016]   |  

Abstract

Investigation of the ethanol extract of the whole plant of Ainsliaea yunnanensis led to the isolation of four new dimeric sesquiterpene lactones, ainsliadimer F–I (14), together with seven known dimeric sesquiterpene lactones (511) and ten sesquiterpenes (1221). Their structures were elucidated by spectroscopic methods. The relative stereochemistry of ainsliadimer F was further confirmed by single crystal X-ray diffraction analysis. Compounds 121 were tested for the inhibition of nuclear factor kappa B (NF-κB) in the 293-NF-κB-luciferase reporter cell line induced by lipopolysaccharide (LPS), and Compounds 5, 18, 20 and 21 were further tested for the production of TNF-α, IL-1β, IL-6 and IL-10 in RAW 264.7 macrophages induced by LPS. Compounds 5, 18, 20 and 21 exhibited significant activity in anti-inflammatory activity assays. View Full-Text
Keywords: Ainsliaea yunnanensis; Ainsliaea; sesquiterpenoid; anti-inflammatory activity Ainsliaea yunnanensis; Ainsliaea; sesquiterpenoid; anti-inflammatory activity
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Wu, X.-L.; Xiong, X.-J.; Lu, W.-Q.; Huang, H.; Shen, Y.-H.; Wu, Z.-J.; Chen, W.-S. New Sesquiterpenenoids from Ainsliaea yunnanensis. Molecules 2016, 21, 1031.

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