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Molecules 2016, 21(8), 1022; doi:10.3390/molecules21081022

Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice

1
Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea
2
Division of Food Biotechnology, University of Science & Technology, Daejeon 34113, Korea
These authors contributed equally in this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 June 2016 / Revised: 21 July 2016 / Accepted: 30 July 2016 / Published: 5 August 2016
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Abstract

In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice. Moreover, to determine the neurobiological effects underlying the ameliorating effects of the DMC, choline acetyltransferase (ChAT) immunoreactivity was evaluated in mice exposed to scopolamine. Our results demonstrated that chronic oral administration (28 days) of DMC (10 mg/kg) improved scopolamine-induced learning impairment in the passive avoidance task and memory impairment in the Morris water maze. Moreover, Choline acetyltransferase (ChAT) activity in the DMC-treated group was significantly increased to 33.03% compared with the control group. Our present finding suggests that DMC ameliorates memory impairments induced by scopolamine treatment through reversing the reduction of hippocampal ChAT expression in mice. View Full-Text
Keywords: demethoxycurcumin; scopolamine; acetyltransferase; passive avoidance task; Morris water maze demethoxycurcumin; scopolamine; acetyltransferase; passive avoidance task; Morris water maze
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Lim, D.W.; Son, H.J.; Um, M.Y.; Kim, I.-H.; Han, D.; Cho, S.; Lee, C.-H. Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice. Molecules 2016, 21, 1022.

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