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Molecules 2016, 21(7), 956; doi:10.3390/molecules21070956

Qingxuan Jiangya Decoction Reverses Vascular Remodeling by Inducing Vascular Smooth Muscle Cell Apoptosis in Spontaneously Hypertensive Rats

1
College of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Minhou Shangjie, Fuzhou 350122, Fujian, China
2
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Minhou Shangjie, Fuzhou 350122, Fujian, China
3
Fuqing Health and Family Planning Bureau, 23 Futang Road, Fuqing 350300, Fujian, China
4
Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Minhou Shangjie, Fuzhou 350122, Fujian, China
5
Case Western Reserve University School of Medicine, Rainbow Babies and Children’s Hospital, Cleveland, OH 44106, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Atanas G. Atanasov, Karel Šmejkal and Elke Heiss
Received: 4 May 2016 / Revised: 17 July 2016 / Accepted: 19 July 2016 / Published: 22 July 2016
(This article belongs to the Special Issue Effects of Natural Products in the Context of Cardiometabolic Disease)
View Full-Text   |   Download PDF [4483 KB, uploaded 22 July 2016]   |  

Abstract

Qingxuan Jiangya Decoction (QXJYD), a traditional Chinese medicine formula prescribed by academician Ke-ji Chen, has been used in China to clinically treat hypertension for decades of years. However, the molecular mechanisms of its action remain largely unknown. In this study, we examined the therapeutic efficacy of QXJYD against elevated systolic blood pressure in the spontaneously hypertensive rat (SHR) model, and investigated the underlying molecular mechanisms. We found that oral administration of QXJYD significantly reduced the elevation of systolic blood pressure in SHR but had no effect on body weight change. Additionally, QXJYD treatment significantly decreased the media thickness and ratio of media thickness/lumen diameter in the carotid arteries of SHR. Moreover, QXJYD remarkably promoted apoptosis of vascular smooth muscle cells and reduced the expression of anti-apoptotic B-cell leukemia/lymphoma 2. Furthermore, QXJYD significantly decreased the plasma Angiotensin II level in SHR. Collectively, our findings suggest that reversing vascular remodeling via inducing VSMC apoptosis could be one of the mechanisms whereby QXJYD treats hypertension. View Full-Text
Keywords: Qingxuan Jiangya Decoction; vascular remodeling; vascular smooth muscle cell; apoptosis; spontaneously hypertensive rats Qingxuan Jiangya Decoction; vascular remodeling; vascular smooth muscle cell; apoptosis; spontaneously hypertensive rats
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MDPI and ACS Style

Xiao, F.; He, F.; Chen, H.; Lin, S.; Shen, A.; Chen, Y.; Chu, J.; Peng, J. Qingxuan Jiangya Decoction Reverses Vascular Remodeling by Inducing Vascular Smooth Muscle Cell Apoptosis in Spontaneously Hypertensive Rats. Molecules 2016, 21, 956.

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