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Molecules 2016, 21(7), 874; doi:10.3390/molecules21070874

Enhancement of Exposure and Reduction of Elimination for Paeoniflorin or Albiflorin via Co-Administration with Total Peony Glucosides and Hypoxic Pharmacokinetics Comparison

1
Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
2
Core Facilities Center, Capital Medical University, Beijing 100069, China
3
Beijing Laboratory for Biomedical Detection Technology and Instrument, Beijing 100069, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 5 April 2016 / Revised: 21 June 2016 / Accepted: 28 June 2016 / Published: 1 July 2016
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [1719 KB, uploaded 1 July 2016]   |  

Abstract

There is evidence suggesting that herbal extracts demonstrate greater bioactivities than their isolated constituents at an equivalent dose. This phenomenon could be attributed to the absence of interacting substances present in the extracts. By measuring the pharmacokinetic parameters of paeoniflorin (PF) and albiflorin (AF) after being orally administered to rats in isolated form, in combination with each other and within total peony glucosides (TPG), respectively, the current study aimed to identify positive pharmacokinetic interactions between components of peony radix extracts. Moreover, the pharmacokinetic profiles of PF and AF under normoxia and hypoxia were also investigated and compared. In order to achieve these goals, a highly sensitive and reproducible ultra-peformance liquid chromatography–mass spectrometry (UPLC-MS) method was developed and validated for simultaneously quantitation of PF and AF in rat plasma. This study found that compared with that of single component (PF/AF), the exposure of PF in rat plasma after combination administration or TPG administration was significantly increased, meanwhile the elimination of PF/AF was remarkably reduced. It was also noticed that AUC and Cmax of PF in hypoxia rats were significantly decreased compared with that of normaxia rats, suggesting that there was a decreased exposure of PF in rats under hypoxia. The current study, for the first time, revealed the pharmacokinetic interactions between PF/AF and other constitutes in TGP and the pharmacokinetic profiles of PF and AF under hypoxia. In view of the current findings, it could be supposed that the clinical performance of total peony glucosides would be better than that of single constitute (PF/AF). The outcomes of this animal study are expected to serve as a basis for development of clinical guidelines on total peony glucosides usage. View Full-Text
Keywords: paeoniflorin; albiflorin; total peony glucosides; pharmacokinetics; interaction; hypoxic; UPLC-MS/MS paeoniflorin; albiflorin; total peony glucosides; pharmacokinetics; interaction; hypoxic; UPLC-MS/MS
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xu, W.; Zhao, Y.; Qin, Y.; Ge, B.; Gong, W.; Wu, Y.; Li, X.; Zhao, Y.; Xu, P.; Xue, M. Enhancement of Exposure and Reduction of Elimination for Paeoniflorin or Albiflorin via Co-Administration with Total Peony Glucosides and Hypoxic Pharmacokinetics Comparison. Molecules 2016, 21, 874.

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