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Molecules 2016, 21(6), 806; doi:10.3390/molecules21060806

Exploiting the Biosynthetic Potential of Type III Polyketide Synthases

1
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
2
NUS Synthetic Biology for Clinical and Technological Innovation, Centre for Life Sciences, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Kira Weissman
Received: 20 May 2016 / Revised: 15 June 2016 / Accepted: 17 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Polyketides)

Abstract

Polyketides are structurally and functionally diverse secondary metabolites that are biosynthesized by polyketide synthases (PKSs) using acyl-CoA precursors. Recent studies in the engineering and structural characterization of PKSs have facilitated the use of target enzymes as biocatalysts to produce novel functionally optimized polyketides. These compounds may serve as potential drug leads. This review summarizes the insights gained from research on type III PKSs, from the discovery of chalcone synthase in plants to novel PKSs in bacteria and fungi. To date, at least 15 families of type III PKSs have been characterized, highlighting the utility of PKSs in the development of natural product libraries for therapeutic development. View Full-Text
Keywords: chalcone synthase; stilbene synthase; polyketide; precursor-directed combinatorial biosynthesis; synthetic enzymology chalcone synthase; stilbene synthase; polyketide; precursor-directed combinatorial biosynthesis; synthetic enzymology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lim, Y.P.; Go, M.K.; Yew, W.S. Exploiting the Biosynthetic Potential of Type III Polyketide Synthases. Molecules 2016, 21, 806.

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