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Molecules 2016, 21(6), 803; doi:10.3390/molecules21060803

Flavonoid Glycosides and Their Derivatives from the Herbs of Scorzonera austriaca Wild

1
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China
2
Department of Pharmacy, the Second Part of First Hospital, Jilin University, Changchun 130021, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 22 May 2016 / Revised: 15 June 2016 / Accepted: 17 June 2016 / Published: 21 June 2016
(This article belongs to the Section Natural Products)
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Abstract

Five flavonoid glycosides and two derivatives were isolated from the herbs of Scorzonera austriaca Wild by silica gel column chromatography and preparative HPLC. Their structures were identified, using chemical and spectroscopic methods, as 5,7,4′-trihydroxyflavone 6-C-(2''-O-β-d-glucopyranosyl β-d-glucopyranoside) (1), 5,7,3′,4′-tetrahydroxyflavone 6-C-(2''-O-β-d-glucopyranosyl β-d-glucopyranoside) (2), quercetin 3-O-rutinoside (3), 5,7,4′-trihydroxyflavone 6-C-β-d-glucopyranoside (4), 3′-methoxy-5,7,4′-trihydroxyflavone 6-C-β-d-glucopyranoside (5), 5,7,4′-trihydroxyflavone 8-C-(6''-O-trans-caffeoyl β-d-glucopyranoside) (6), and 5,7,3′,4′-tetrahydroxyflavone 8-C-(6''-O-trans-caffeoyl β-d-glucopyranoside) (7). Compounds 6 and 7 are new flavonoid glycoside derivatives, and compounds 15 were isolated from the herbs of Scorzonera austriaca for the first time. Compounds 6 and 7 were also assayed for their hepatoprotective activities with rat hepatocytes in vitro. View Full-Text
Keywords: Scorzonera austriaca; flavonoids; hepatoprotective activities Scorzonera austriaca; flavonoids; hepatoprotective activities
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MDPI and ACS Style

Xie, Y.; Guo, Q.-S.; Wang, G.-S. Flavonoid Glycosides and Their Derivatives from the Herbs of Scorzonera austriaca Wild. Molecules 2016, 21, 803.

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