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Molecules 2016, 21(6), 756; doi:10.3390/molecules21060756

Antifungal Activity and Biochemical Response of Cuminic Acid against Phytophthora capsici Leonian

Research and Development Center of Biorational Pesticides, Northwest A & F University, Yangling 712100, China
These authors contributed equally to this work.
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Academic Editor: Derek J. McPhee
Received: 21 April 2016 / Revised: 3 June 2016 / Accepted: 6 June 2016 / Published: 11 June 2016
(This article belongs to the Section Natural Products)
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Abstract

Phytophthora blight of pepper caused by Phytophthora capsici Leonian is a destructive disease throughout the world. Cuminic acid, extracted from the seed of Cuminum cyminum L., belongs to the benzoic acid chemical class. In this study, the sensitivity and biochemical response of P. capsici to cuminic acid was determined. The mean EC50 (50% effective concentration) values for cuminic acid in inhibiting mycelial growth and zoospore germination of the 54 studied P. capsici isolates were 14.54 ± 5.23 μg/mL and 6.97 ± 2.82 μg/mL, respectively. After treatment with cuminic acid, mycelial morphology, sporangium formation and mycelial respiration were significantly influenced; cell membrane permeability and DNA content increased markedly, but pyruvic acid content, adenosine triphosphate (ATP) content, and ATPase activity decreased compared with the untreated control. In pot experiments, cuminic acid exhibited both protective and curative activity. Importantly, POD and PAL activity of the pepper leaves increased after being treated with cuminic acid. These indicated that cuminic acid not only showed antifungal activity, but also could improve the defense capacity of the plants. All the results suggested that cuminic acid exhibits the potential to be developed as a new phytochemical fungicide, and this information increases our understanding of the mechanism of action of cuminic acid against Phytophthora capsici. View Full-Text
Keywords: antifungal activity; cuminic acid; Phytophthora capsici; biochemical response; defense capacity antifungal activity; cuminic acid; Phytophthora capsici; biochemical response; defense capacity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, Y.; Sun, Y.; Zhang, Y.; Zhang, X.; Feng, J. Antifungal Activity and Biochemical Response of Cuminic Acid against Phytophthora capsici Leonian. Molecules 2016, 21, 756.

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