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Molecules 2016, 21(6), 743; doi:10.3390/molecules21060743

Antimicrobial Activity and Modulatory Effect of Essential Oil from the Leaf of Rhaphiodon echinus (Nees & Mart) Schauer on Some Antimicrobial Drugs

1
Centro de Ciências Biológicas e da Saúde (CC BS), Departamento de Ciências Biológicas, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil
2
Programa de Pós-Graduação em Bioquímica Toxicológica, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil
3
Molecular Chemistry and Pharmacology Laboratory, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil
4
Laboratório de Botânica Aplicada, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil
5
Departamento de Bioquímica, Instituto de Ciências Básica da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-191, RS, Brazil
6
Laboratory of Microbiology and Molecular Biology, Universidade Regional do Cariri (URCA), Crato 63105-000, CE, Brazil
7
Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Luca Forti
Received: 3 April 2016 / Revised: 30 May 2016 / Accepted: 31 May 2016 / Published: 8 June 2016
(This article belongs to the Collection Recent Advances in Flavors and Fragrances)
View Full-Text   |   Download PDF [1373 KB, uploaded 8 June 2016]   |  

Abstract

Background: Rhaphiodon echinus is a weed plant used in the Brazilian folk medicinal for the treatment of infectious diseases. In this study, the essential oil of R. echinus leaf was investigated for its antimicrobial properties. Methods: The chemical constituents of the essential oil were characterized by GC-MS. The antimicrobial properties were determined by studying by the microdilution method the effect of the oil alone, and in combination with antifungal or antibiotic drugs against the fungi Candida albicans, Candida krusei and Candida tropicalis and the microbes Escherichia coli, Staphylococcus aureus and Pseudomonas. In addition, the iron (II) chelation potential of the oil was determined. Results: The results showed the presence of β-caryophyllene and bicyclogermacrene in major compounds, and revealed a low antifungal and antibacterial activity of the essential oil, but a strong modulatory effect on antimicrobial drugs when associated with the oil. The essential oil showed iron (II) chelation activity. Conclusions: The GC-MS characterization revealed the presence of monoterpenes and sesquiterpenes in the essential oil and metal chelation potential, which may be responsible in part for the modulatory effect of the oil. These findings suggest that essential oil of R. echinus is a natural product capable of enhancing the antibacterial and antifungal activity of antimicrobial drugs. View Full-Text
Keywords: natural products; R. echinus; antibacterial activity; antifungal activity; modulating natural products; R. echinus; antibacterial activity; antifungal activity; modulating
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Duarte, A.E.; de Menezes, I.R.A.; Bezerra Morais Braga, M.F.; Leite, N.F.; Barros, L.M.; Waczuk, E.P.; Pessoa da Silva, M.A.; Boligon, A.; Teixeira Rocha, J.B.; Souza, D.O.; Kamdem, J.P.; Melo Coutinho, H.D.; Escobar Burger, M. Antimicrobial Activity and Modulatory Effect of Essential Oil from the Leaf of Rhaphiodon echinus (Nees & Mart) Schauer on Some Antimicrobial Drugs. Molecules 2016, 21, 743.

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