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Molecules 2016, 21(5), 659; doi:10.3390/molecules21050659

Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation

1
Department of Chemistry, Karadeniz Technical University, Trabzon 61080, Turkey
2
Department of Biology, Recep Tayyip Erdoğan University, Rize 53100, Turkey
3
Faculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, Turkey
*
Author to whom correspondence should be addressed.
Academic Editor: Derek McPhee
Received: 3 March 2016 / Revised: 22 April 2016 / Accepted: 11 May 2016 / Published: 19 May 2016
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [851 KB, uploaded 19 May 2016]   |  

Abstract

A series of symmetric bis-1,2,3-triazole compounds 2–5(a–f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by 1H-NMR and 13C-NMR. All of the synthesized compounds were subjected to antioxidant and antimicrobial assays. The antioxidant activity of these compounds (AChE inhibition, DPPH and SOD activities) was evaluated. Compound 2f was found to show the highest AChE inhibition activity of all compounds, while compound 3b showed a strong inhibitory effect on DPPH radical and compound 2a was the most effective of all compounds for SOD activity. All synthesized compounds were found to possess moderate antibacterial activity against the bacteria E. coli and Y.pseudotuberculosis. View Full-Text
Keywords: 1,2,3-triazole; 1,3-dipolar cycloaddition; antioxidant activity; antimicrobial activity 1,2,3-triazole; 1,3-dipolar cycloaddition; antioxidant activity; antimicrobial activity
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Düğdü, E.; Ünlüer, D.; Çelik, F.; Sancak, K.; Alpay Karaoğlu, Ş.; Özel, A. Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation. Molecules 2016, 21, 659.

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